GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs12780845 | 1 | rs12782687 | chr10:17223368 | CUBN | chr10:16865966-17171816:- | 0.32 | 5.06 | 2.02E-6 | Homocysteine levels |
| THYM | cis | rs12780845 | 1 | rs12783490 | chr10:17223716 | CUBN | chr10:16865966-17171816:- | 0.32 | 4.95 | 3.16E-6 | Homocysteine levels |
| THYM | cis | rs975752 | 1 | rs12806 | chr10:101911142 | BLOC1S2 | chr10:102033713-102046439:- | -0.49 | -5.32 | 6.95E-7 | Schizophrenia |
| THYM | cis | rs2120019 | 1 | rs12898259 | chr15:75369780 | PPCDC | chr15:75315927-75343066:+ | 0.26 | 4.7 | 8.93E-6 | Blood trace element (Zn levels) |
| THYM | cis | rs2120019 | 1 | rs12901243 | chr15:75374233 | PPCDC | chr15:75315927-75343066:+ | 0.26 | 4.7 | 8.93E-6 | Blood trace element (Zn levels) |
| THYM | cis | rs2120019 | 1 | rs12903201 | chr15:75370776 | PPCDC | chr15:75315927-75343066:+ | 0.26 | 4.7 | 8.93E-6 | Blood trace element (Zn levels) |
| THYM | cis | rs2028299 | 1 | rs12910992 | chr15:90372465 | AP3S2 | chr15:90373832-90456222:- | -0.42 | -4.68 | 9.6E-6 | Type 2 diabetes |
| THYM | cis | rs9894429 | 1 | rs12948099 | chr17:79600799 | TSPAN10 | chr17:79609349-79615778:+ | 0.63 | 6.54 | 3.14E-9 | Eye color traits |
| THYM | cis | rs7246967 | 1 | rs12980225 | chr19:23026745 | ZNF492 | chr19:22817126-22850472:+ | -0.5 | -5.66 | 1.61E-7 | Bronchopulmonary dysplasia |
| THYM | cis | rs7246967 | 1 | rs12983770 | chr19:23023614 | ZNF492 | chr19:22817126-22850472:+ | -0.5 | -5.66 | 1.61E-7 | Bronchopulmonary dysplasia |
| THYM | cis | rs1299548 | 1 | rs1299548 | chr7:7302293 | C1GALT1 | chr7:7222246-7283979:+ | -0.29 | -4.17 | 6.79E-5 | Visceral adipose tissue adjusted for BMI |
| THYM | cis | rs7608910 | 1 | rs13003464 | chr2:61186829 | C2orf74 | chr2:61372243-61391964:+ | 0.39 | 4.35 | 3.4E-5 | Crohn's disease;Ulcerative colitis;Inflammatory bowel disease |
| THYM | cis | rs4663866 | 1 | rs13026475 | chr2:239178455 | LOC151174 | chr2:239133754-239140318:- | 0.93 | 4.57 | 1.47E-5 | Irritable bowel syndrome |
| THYM | cis | rs4663866 | 1 | rs13033501 | chr2:239181860 | LOC151174 | chr2:239133754-239140318:- | 0.89 | 4.51 | 1.84E-5 | Irritable bowel syndrome |
| THYM | cis | rs911119 | 1 | rs13038305 | chr20:23610262 | CST9 | chr20:23583049-23586610:- | -0.51 | -4.73 | 7.71E-6 | Chronic kidney disease |